In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 289039-29-8 as follows. Product Details of 289039-29-8
2-chloro-5-iodo-benzamidine 374.8 mL (374.8 mmol) lithium bis-trimethylsilylamide (1 M in hexane) are placed in 300 mL diethyl ether and combined with 50.0 g (189.8 mmol) 2-chloro-5-iodobenzonitrile. The reaction mixture is stirred for 1.5 hours at ambient temperature under an argon atmosphere and then cooled to 0 C. Then 5 molar hydrochloric acid is slowly added. The precipitate thus formed is suction filtered and dried. Yield: 56.0 g
According to the analysis of related databases, 289039-29-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Brandl, Trixi; Maier, Udo; Hoffmann, Matthias; Scheuerer, Stefan; Joergensen, Anne T.; Pautsch, Alexander; Breitfelder, Steffen; Grauert, Matthias; Hoenke, Christoph; Erb, Klaus; Pieper, Michael; Pragst, Ingo; US2007/244104; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com