These common heterocyclic compound, 696-41-3, name is 3-Iodobenzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: iodides-buliding-blocks
100ml three-necked flaskM-iodobenzaldehyde(10.8mmol, 2.51g),Benzoquinone hydrochloride(21.6mmol, 3.80g), Na2CO3 (21.6 mmol, 2.2 g),Cu(OAc) 2 (1.08 mmol, 0.21 g),The molar ratio is charged at 1:2:2:0.1.The solvent was chosen to be 50 g of toluene.The reaction was controlled to stir at 110 C for 12 h.filter,Washed,Recrystallization from absolute ethanol,The obtained cake was vacuum dried to obtain a product of 4.05 g.The yield was 86%.
The synthetic route of 3-Iodobenzaldehyde has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hubei Shang Sai Optoelectric Materials Co., Ltd.; Mu Guangyuan; Zhuang Shaoqing; Wang Qi; (18 pag.)CN108264490; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com