Related Products of 355-43-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 355-43-1 name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a three-necked flask (200 mL) equipped with a condenser tube, 8.93 g (20.0 mmol) of perfluorohexyl iodide, 1.70 g (10.0 mmol) of 10-undecenol, 0.657 g of azobisisobutyronitrile (4.00 mmol), and the interior of the vessel was purged with argon and then heated at 80 C. for 8 hours with stirring. The reaction mixture was dissolved in 100 ml of ethanol and 5.00 g (76.5 mmol) of zinc powder was added and stirred for 15 minutes, then 3.00 g (50.0 mmol) of acetic acid was added and the mixture was heated under reflux for 5 hours. After cooling to room temperature, it was filtered through celite to remove residual zinc powder. After concentrating the filtrate under reduced pressure, diethyl ether was added and washed with water to remove excess acetic acid. After concentration under reduced pressure, recrystallization in hexane gave 4.04 g (yield 82%) of fluorinated alcohol (III-1) C 6 F 13 – (CH 2) 11 -OH.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, and friends who are interested can also refer to it.
Reference:
Patent; NEOS Corporation; Morioka, Kyoichi; Miyata, Koji; Terauchi, Shunji; Narimatsu, Shinsuke; Umeda, Takahiko; (14 pag.)JP6091963; (2017); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com