Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16932-44-8, name is 2-Iodo-1,3-dimethoxybenzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Iodo-1,3-dimethoxybenzene
General procedure: An oven dried pressure tube was charged with aryl halide (0.5mmol), CuI (10-25mol%), anhydrous Zn(OAc)2 (1.5-2equiv) and anhydrous DMSO (1.6mL). The tube was sealed with a Teflon screw cap and stirred at 135C for 24-36h. The reaction mixture was then cooled to room temperature and stirred in 10mL of diethyl ether for 5min. It is filtered through a sintered funnel and the filtrate is washed with excess ice cold water and further extracted with diethyl ether (3¡Á10mL). The combined organic extracts were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give the crude product, which was purified by column chromatography using 200-400 mesh silica gel and a mixture of diethyl ether and hexane (or pentane, for Table 2, entries 2, 8, 10, 14, 16 and 24) as eluents to afford the desired products in good yields.
The synthetic route of 16932-44-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Joseph, P.J. Amal; Priyadarshini; Kantam, M. Lakshmi; Sreedhar; Tetrahedron; vol. 69; 38; (2013); p. 8276 – 8283;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com