Related Products of 34270-90-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 34270-90-1 name is 1-Iodo-2-(2-iodoethoxy)ethane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: HCl (50 mg, 0.18 mmol) was added to 15 mL of an anhydrous DMF solution containing pre-washed NaH (60% oil mixture) (14 mg, 0.36 mmol) and 7-MEOTA at 0 C, and stirred for 30 min at room temperature. The bis-iodo compound dissolved in 2 mL of anhydrous DMF (29 mg, 0.09 mmol of 15, 33 mg, 0.09 mmol of 16, and 37 mg,0.09 mmol of 17) was added dropwise and the resulting solution was stirred for 10 h at 110 C. The resulting mixtures were extracted with EtOAc. The extract was dried with MgSO4, filtered,and concentrated in vacuo. The resulting residue was subjected to silica gel column chromatography (EtOAc) to afford tacrine dimers 3 (16 mg, 34%), 4 (17 mg, 33%), and 5 (21 mg, 38%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Iodo-2-(2-iodoethoxy)ethane, and friends who are interested can also refer to it.
Reference:
Article; Lee, Sang Kwang; Park, Min Kyun; Jhang, Ho Eun; Yi, Jinju; Nahm, Keepyong; Cho, Dae Won; Ra, Choon Sup; Musilek, Kamil; Horova, Anna; Korabecny, Jan; Dolezal, Rafael; Jun, Daniel; Kuca, Kamil Kuca; Bulletin of the Korean Chemical Society; vol. 36; 6; (2015); p. 1654 – 1660;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com