Synthetic Route of 444-29-1, The chemical industry reduces the impact on the environment during synthesis 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, I believe this compound will play a more active role in future production and life.
Example 9; 2-Ethyl-1- [3-(2-trifluoromethylphenyl)-2-propynyl]-1 H-imidazo [4,5-c] quinolin-4-amine; Part A; Tris (dibenzylideneacetone) dipalladium (0) chloroform adduct (64.5 mg, 0.03 eq. ), 2-iodobenzotrifluoride (321 uL, 1.1 eq. ), triethylamine (869 muL, 3.0 eq. ), and copper (I) iodide (23.7 mg, 0.06 eq. ) were added sequentially to a solution of 2-ethyl-1- (2-propynyl)- 1H-imidazo [4,5-c] quinoline (489 mg, 2.08 mmol, 1.0 eq. ) in DMF (10.6 mL). The reaction mixture was stirred at ambient temperature for 18 hours and then concentrated under reduced pressure. The residue was purified by column chromatography (silica gel eluting with 3/97 methanol/chloroform) to provide 0.13 g of 2-ethyl-1- [3- (2- trifluoromethylphenyl)-2-propynyl]-lH-imidazo [4,5-c] quinoline as a light yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-2-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2005/66170; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com