Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 123158-75-8, name is 4-Chloro-2-iodo-6-nitroaniline, A new synthetic method of this compound is introduced below., Quality Control of 4-Chloro-2-iodo-6-nitroaniline
2-Amino-5-chloro-3-nitro-phenyliodide (1.5 g, 4.90 mmol) prepared in Preparation 19 and 1-phenyl-2-trimethylsilylacetylene (4.3 g, 24.50 mmol) were dissolved in DMF (50 mL). Palladium acetate (0.11 g, 0.5 mmol), lithium chloride (0.21 g, 4.90 mmol) and triethylamine (2.48 g, 24.50 mmol) were added thereto, and the mixture was stirred under heating for 3 h to 100 C. After completion of the reaction, water was added to the reaction mixture, which was then extracted with ethyl acetate, washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and filtered. The solvent was removed under reduced pressure, and the residue was purified by column chromatography to give the title compound (1.05 g, Yield 87%).
The synthetic route of 123158-75-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG Life Sciences Ltd.; Kim, Sun Ha; Kim, Hyung Jin; Ku, Son Young; Jong, Chol Woong; Choe, Dok Young; Lee, Song Bae; Park, Hee Sul; Yun, Sung Hyun; Kwak, Hyo Sin; Kim, Song Wook; Saw, Dong Wook; Park, Aok; Im, Hyun Ju; Won, Jong Hon; Baek, Sung Yeop; (75 pag.)KR101511771; (2015); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com