Adding a certain compound to certain chemical reactions, such as: 204257-72-7, name is Methyl 2-fluoro-4-iodobenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 204257-72-7, Recommanded Product: Methyl 2-fluoro-4-iodobenzoate
4-bromo-2-fluorobenzeneboronic acid (0.50 g, 2.28 mmol) was added to a single-mouth bottle.Methyl 2-fluoro-4-iodobenzoate (0.57 g, 2.06 mmol),Potassium carbonate (0.95 g, 6.87 mmol) and[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloride (84 mg, 0.11 mmol).The reaction was stirred at 100 C for 1 h and then concentrated under reduced pressure.The residue obtained was subjected to silica gel column chromatography(PE/EA(V/V)=100/1)Purified to give the title compound as a colorless oil(0.39 g, 52%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-fluoro-4-iodobenzoate, and friends who are interested can also refer to it.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Liu Xinchang; Huang Jianzhou; Zhang Yingjun; S ¡¤geerdeman; (267 pag.)CN109111451; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com