Adding a certain compound to certain chemical reactions, such as: 1643-29-4, name is 3-(4-Iodophenyl)propanoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1643-29-4, Recommanded Product: 3-(4-Iodophenyl)propanoic acid
A suspension of 3-(4-iodophenyl)propanoic acid (19) (0.50 g,1.81 mmol), bis(pinacolato)diboron (0.69 g, 2.72 mmol), and KOAc(0.71 g, 7.24 mmol) in DMF (1 ml) was degassed by bubbling argon through the mixture for 15 min, then Pd(dppf)Cl2 (66 mg,0.09 mmol) was added to this mixture. The reaction was heated to 80 C for 2.5 h. The reaction mixture was cooled to rt, filtered through a pad of silica gel, and washed with EtOAc. The filtrate was concentrated under reduced pressure and purified by column chromatography on silica gel (EtOAc in petroleum ether, 1:2) to give the product 20 (0.32 g, 63%) as a white solid. 1H NMR(300 MHz, CDCl3) d: 10.43 (b s, 1H), 7.75 (d, J = 8.0 Hz, 2H), 7.22(d, J = 8.0 Hz, 2H), 2.98 (t, J = 7.8 Hz, 2H), 2.68 (t, J = 7.8 Hz, 2H),1.34 (s, 12H). LCMS (ESI) m/z: 277.09 [M+H]+.
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Reference:
Article; Bobileva, Olga; Ikaunieks, Martins; Duburs, Gunars; Mandrika, Ilona; Petrovska, Ramona; Klovins, Janis; Loza, Einars; Bioorganic and Medicinal Chemistry; vol. 25; 16; (2017); p. 4314 – 4329;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com