Adding a certain compound to certain chemical reactions, such as: 135050-44-1, name is 3-Chloro-4-iodoaniline, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 135050-44-1, HPLC of Formula: C6H5ClIN
A solution of sodium nitrite (3.27g) in water was added dropwise over 1H to a stirred solution OF 3-CHLORO-4-IODOANILINE (LO. OG) in a mixture of THF (120ML) and concentrated hydrochloric acid (50ml) at-5 TO-1C. Magnesium chloride (6.39g) was then added and the resulting mixture poured into a stirred solution of acetic acid (50ml) saturated with sulfur dioxide and containing cuprous chloride (2.14g). After heating at 34C for 30MIN, the mixture was poured into brine, extracted with EtOAc, washed with aqueous sodium bicarbonate and brine, dried (MGS04) and evaporated. The residue was dissolved in THF (100ml), 0.880 ammonia (100ml) added and stirred for 2h. The mixture was diluted with brine, extracted with EtOAc, washed with brine, dried (MGS04) and evaporated. The residue was treated with isohexane/ether (4: 1) and filtered to give the subtitle compound. Yield 5.67g. 1H NMR DMSO-d6: No. 8.18 (d, 1H), 7.92 (d, 1H), 7.56 (s, 1H), 7.47 (dd, 1H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-4-iodoaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; WO2004/89885; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com