Electric Literature of 460-37-7,Some common heterocyclic compound, 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, molecular formula is C3H4F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1.0 g (3.40 mmol) of the compound from Ex. 289A and 1.17 g (8.49 mmol) of potassium carbonate were stirred in 25 ml of anhydrous DMF at RT for 15 min, before 2.28 g (10.2 mmol) of 1,1,1-trifluoro-3-iodopropane were added. Then the reaction mixture was stirred at 50 C. for about 16 h. After cooling to RT, water was added thereto and it was stirred at RT for 30 min. The product which precipitated out was filtered off with suction, washed with a little water and dried under high vacuum. 1.23 g (91% of theory) of the title compound were obtained. 1H-NMR (400 MHz, DMSO-d6, delta/ppm): 4.29 (q, 2H), 4.12 (t, 2H), 2.87-2.68 (m, 2H), 2.76 (s, 3H), 2.65-2.58 (m, 1H), 1.30 (t, 3H), 1.08-0.98 (m, 2H), 0.73-0.64 (m, 2H). LC/MS (Method 1, ESIpos): Rt=2.06 min, m/z=391.09 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1-Trifluoro-3-iodopropane, its application will become more common.
Reference:
Patent; Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; HAERTER, Michael; KOSEMUND, Dirk; CANCHO GRANDE, Yolanda; DELBECK, Martina; KALTHOF, Bernd; LUSTIG, Klemens; SUESSMEIER, Frank; US2020/16159; (2020); A1;,
Iodide – Wikipedia,
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