Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69113-59-3, name is 3-Iodobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3-Iodobenzonitrile
General procedure: General procedure: An oven-dried Schlenk tube containing a magnetic stirring bar was charged with methyl 4-iodobenzoate 2a (52.40 mg, 0.2 mmol), Pd(OAc)2 (2.24 mg, 0.01 mmol) and Ag2CO3 (55.15 mg, 0.2 mmol) under nitrogen. To this mixture was added trimethyl(2-phenylallyl)silane 1a (57.11 mg, 0.3 mmol) and DCE (4 ml) by a syringe. After the reaction completed, it was quenched by saturated NaHCO3 aqueous solution. The mixture was extracted by DCM. Then the combined organic extracts were washed with brine, dried over Na 2 SO 4 and filtered. After concentration, the residue was submitted to flash chromatography on a silica gel column with petroleum ether/dichloromethane (5:1) as the eluent to give the product 3aa as a white solid.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 69113-59-3.
Reference:
Article; Hou, Zhen-Lin; Yang, Fan; Zhou, Zhibing; Ao, Yu-Fei; Yao, Bo; Tetrahedron Letters; vol. 59; 52; (2018); p. 4557 – 4561;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com