Synthetic Route of 626-44-8,Some common heterocyclic compound, 626-44-8, name is 1,3,5-Triiodobenzene, molecular formula is C6H3I3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 1,3,5-triiodobenzene (0.46 g, 1.0 mmol), diphenylphosphine oxide (0.73 g, 3.6 mmol), CuI (0.06 g, 0.30 mmol), l-proline (0.04 g, 0.30 mmol), and Cs2CO3 (1.5 g, 4.5 mmol) was added to toluene solution (30 mL). The mixture was refluxed under nitrogen for 48 h. After the reaction finished, the reaction mixture was extracted with dichloromethane and washed with water. The organic layer was dried by anhydrous MgSO4 and filtered. The product was isolated by silica gel column chromatography using methanol/ethyl acetate (1:5) as eluent to afford a white solid (0.64, 52%). 1H NMR (300 MHz, CDCl3, delta): 8.08 (t, J = 11.9 Hz, 3H), 7.52 (dd, J = 12.9, 7.2 Hz, 18H), 7.39 (dd, J = 9.8, 4.8 Hz, 12H). 13C NMR (75 MHz, CDCl3, delta): 141.05, 141.02, 140.91, 134.89, 134.66, 134.39, 133.00, 131.36, 131.19, 31P NMR (121 MHz, CDCl3, delta): 27.59. HRMS [m/z]: calcd for C42H33O3P3, 678.1643; found, 679.1711 [M+H+]. Anal. Calcd. for C42H33O3P3: C, 74.33; H, 4.90. Found: C, 74.36; H, 4.88.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3,5-Triiodobenzene, its application will become more common.
Reference:
Article; Ban, Xinxin; Sun, Kaiyong; Sun, Yueming; Huang, Bin; Jiang, Wei; Organic electronics; vol. 33; (2016); p. 9 – 14;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com