Some common heterocyclic compound, 3718-88-5, name is 3-Iodobenzylamine hydrochloride, molecular formula is C7H9ClIN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 3-Iodobenzylamine hydrochloride
To 36 B-1 (0.30 g, 1.0 mmol), 818 3-iodobenzylamine hydrochloride (0.33 mg, 1.2 mmol), 14triethylamine (0.43 mL, 3.1 mmol), 169 WSC hydrochloride (0.29 g, 1.5 mmol) and 637 1-hydroxy-7-azabenzotriazole (69 mg, 0.51 mmol) was added 12 dichloromethane (10 mL), and the mixture was stirredat room temperature for 24 hr. To the reaction mixture was added 52 water, and the mixture was extractedwith dichloromethane. The organic layer was dried over sodium sulfate. The desiccant was filtered off, andthe solvent was evaporated. The obtained residue was purified by high performance liquid chromatography(water-acetonitrile, each containing 0.1% 80 trifluoroacetic acid) to give the 819 title compound (0.29 g , 0.56 mmol, 55%). MS (ESI) m/z 511 (M+H)+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3718-88-5, its application will become more common.
Reference:
Patent; EA PHARMA CO., LTD.; KOBAYASHI, Kaori; SUZUKI, Tamotsu; KAWAHIRA, Mizuki; FUJII, Tomohiro; SUGIKI, Masayuki; OHSUMI, Koji; OKUZUMI, Tatsuya; (285 pag.)US2016/332999; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com