Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, This compound has unique chemical properties. The synthetic route is as follows., category: iodides-buliding-blocks
The reference gathers the precedent 11 the obtained 1 – [trans-4 – (hydroxy methyl) cyclohexyl] – 3,7-bis-{ [2 – (trimethyl silicon alkyl) ethoxy] methyl} – 1H-pyrrolo [3 ‘, 2’ : 5,6] pyrido [4,3-d] pyrimidine -2,4 (3H, 7H)-dione (1.35g, 2 . 35mmol) bis methyl chloride (14 ml) is added in the solution 1, 1, 1-trifluoro-3- propyl iodide (1.34 ml, 11 . 8mmol), 2,6-di-tert-butyl pyridine (2.38 ml, 10 . 8mmol) and trifluoro methane sulfonic acid silver (2.60g, 10 . 1mmol), stirring 113 hours. Furthermore, filter the reaction mixture, added to the resulting filtrate extraction of chloroform and water. The resulting organic layer after drying with anhydrous sodium sulfate, concentrated under reduced pressure. Residues to silica gel column chromatography (section 1 time: hexane/ethyl acetate = 1/0 ? 78/22(v/v), paragraph 2 time: hexane/ethyl acetate = 1/0 ? 4/1(v/v), paragraph 3 time: hexane/ethyl acetate = 1/0 ? 4/1(v/v)) purification of 3 time, to obtain the colorless amorphous title compound (1.34g, yield 85%).
According to the analysis of related databases, 460-37-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NISSAN CHEMICAL INDUSTRIES, LTD.; WATANABE, TSUNEO; TAKAHASHI, KEIJI; HAYASHI, KEISHI; NAKAMURA, TAKANORI; MINAMI, MASATAKA; KURIHARA, KAZUNORI; YAMAMOTO, AKIO; NISHIMURA, TAKUYA; UNI, MIYUKI; KAMIYAMA, TOSHIHIKO; IWAMOTO, SHUNSUKE; (96 pag.)TW2016/7947; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com