Adding a certain compound to certain chemical reactions, such as: 624-75-9, name is 2-Iodoacetonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 624-75-9, Formula: C2H2IN
A mixture of (2S,2’S)-3,3′-((((2,2′-dimethyl-[1,1′-biphenyl]-3,3′- diyl)bis(oxy))bis(propane-3,1-diyl))bis(azanediyl))bis(propane-1,2-diol) (Example 2079, 20 mg, 0.042 mmol) and 2-iodoacetonitrile (20 mul, 0.276 mmol) in methanol (1 mL) and N,N-diisopropylethylamine (50 muL, 0.286 mmol) was heated at 65 C for 4 h. The crude material was purified via preparative LC/MS with the following conditions: Column: XBridge C18, 19 x 200 mm, 5-mum particles;Mobile Phase A: 5:95 acetonitrile: water with 10-mM ammonium acetate; Mobile Phase B: 95:5 acetonitrile: water with 10-mM ammonium acetate; Gradient: 25-65% B over 15 minutes, then a 5-minute hold at 100% B; Flow: 20 mL/min to give the pure title compound: (16.1 mg, 64%). LC/MS Condition E: ret time 1.65 min; m/e = 555 (M+H)+. LC/MS Condition F: ret time 1.45 min; m/e = 555 (M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodoacetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; YEUNG, Kap-Sun; GRANT-YOUNG, Katharine A.; ZHU, Juliang; SAULNIER, Mark G.; FRENNESSON, David B.; LANGLEY, David R.; HEWAWASAM, Piyasena; WANG, Tao; ZHANG, Zhongxing; MENG, Zhaoxing; SUN, Li-Qiang; MULL, Eric; SCOLA, Paul Michael; (370 pag.)WO2018/44963; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com