Related Products of 450412-29-0, A common heterocyclic compound, 450412-29-0, name is 1-Bromo-3-fluoro-2-iodobenzene, molecular formula is C6H3BrFI, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
28.3 g (100 mmol, 1.0 eq.) m-bromoiodobenzene and 25.8 g m-bromoaniline (150 mmol, 1.5 eq.)It was placed in a dry 3 L three-necked flask, and then dried and degassed 1100 ml of toluene was added as a solvent.Nitrogen gas was passed for 15 minutes. Add 2.9g (15% mol) of cuprous iodide,5.9 g (30% mol) of 1,10-phenanthroline and 63.7 g (300 mol, 3 eq.) potassium phosphate.The temperature was raised to 110 C and the reaction was carried out for 18 hours. After the reaction is completed, cool to room temperature, suction filtration,Rotating to remove the solvent,Recrystallization with toluene and ethanol,27.8 g of intermediate L were obtained,The yield was 85%.
The synthetic route of 450412-29-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing Gao Guang Semiconductor Materials Co., Ltd.; Jin Zhenyu; Qian Chao; Wang Xiaowei; Dai Peipei; (49 pag.)CN108164511; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com