Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51411-81-5, name is 3-Amino-4-iodobenzoic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Amino-4-iodobenzoic acid
Step 3 Reaction with 1-Hexyne and Trifluoroacetylation To a mixture of 3-amino-4-iodobenzoic acid on Wang resin (loading 0.6 mmol/g; 3.0 g, 1.8 mmol) and 1-hexyne (0.74 g, 9.0 mmol) in DMF (40 mL) was added bis(triphenylphosphine)palladium(II) chloride (0.20 g, 0.28 mmol) and CuI (0.1 g, 0.52 mmol). The mixture was stirred magnetically for 2 h, filtered, and washed with CH2 Cl2. The resin was suspended in CH2 Cl2 (40 mL), cooled (0 C.), and pyridine (1.5 mL) and trifluoroacetic anhydride (2.6 mL) were added. After 2 h, the mixture was filtered, washed with CH2 Cl2, and dried. To confirm that the reactions occured, 100 mg of resin was treated with 50% TFA/CH2 Cl2 for 3 h, filtered, and the filtrate was concentrated to give 9.8 mg of 4-(1-hexynyl)-3-trifluoroacetamidobenzoic acid; 1 H NMR (DMSO-d6) delta 0.95 (t, 3 H), 1.50 (m, 4 H), 2.95 (m, 2 H), 7.60 (d, 1 H), 7.85 (d, 1 H), 7.90 (s, 1 H), 11.20 (s, 1 H). Anal. calc’d for C15 H14 F3 NO3: C, 57.51; H, 4.50; N, 4.47; Found: C, 57.20; H, 4.38; N, 4.46.
The synthetic route of 51411-81-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; American Home Products Corporation; US5932743; (1999); A;,
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