Application of 6937-34-4, These common heterocyclic compound, 6937-34-4, name is 3-Iodophthalic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0591] To a solution of 3-iodophthalic acid (5.0 g, 17.1 mmol) in THF (75 mL) was added acetic anhydride (25 mL) at rt. The mixture was heated to 85C and stirred for 6 hrs. The reaction was cooled to rt and concentrated, providing 4-iodoisobenzofuran-1,3- dione (4.59 g, 98% yield) as a yellow solid. MS (ESI) m/z = 275 [M+H]+. 1H NMR (DMSO-d6, 400 MHz) ^: 8.39 (d, J = 8.0 Hz, 1 H), 8.06 (d, J = 7.2 Hz, 1 H), 7.66 (t, J = 7.6 Hz, 1 H).
Statistics shows that 3-Iodophthalic acid is playing an increasingly important role. we look forward to future research findings about 6937-34-4.
Reference:
Patent; BIOTHERYX, INC.; CHAN, Kyle, W.H.; FUNG, Leah; SULLIVAN, Robert; ERDMAN, Paul, E.; MERCURIO, Frank; (225 pag.)WO2017/201069; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com