Reference of 76801-93-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 76801-93-9 as follows.
The above white powder compound (10 g, 14.2 mmol) was dissolved in 20 mL of DMAcIn a mixture with acetonitrile (1:1), the temperature is lowered to 10 C, and the temperature is controlled below 30 C.Dropping (the purpose of dropping is controlled to a temperature not exceeding 30 C) Chloroacetyl chloride(9.65g, 92.3mmol), after the addition was completed, the temperature was raised to 50 C, and after stirring for 3 hours,Cool to 15 C, drop (the purpose of the drop control temperature does not exceed 25 C)20mL 10mol / L NaOH aqueous solution, stirring reaction at 25 C for 1 h,After the reaction was completed, the pH was adjusted to 4 with dilute hydrochloric acid, and the mixture was allowed to stand overnight at 0 C, and filtered.The filter cake is washed several times with water and dried (dried to sample to 85 C).GotN,N-(2′,3′)-Dihydroxypropyl-3,5-dimethylformamide-(2,4,6-)beta-amino group.
According to the analysis of related databases, 76801-93-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; China Calculate University; Wu Zhiping; Bai Xueyan; Wu Yuqi; (13 pag.)CN108727376; (2018); A;,
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