Electric Literature of 2401-21-0, A common heterocyclic compound, 2401-21-0, name is 1,2-Dichloro-3-iodobenzene, molecular formula is C6H3Cl2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
E. 17alpha-Chloro-17beta-(4′-Chlorobenzylsulfinyl)-1,4-Androstadiene-3,11-Dione In a manner similar to that described in Example 2A, react 0.4 gm. of 17alpha-(4′-chlorobenzylthio)-1,4-androstadiene-3,11-dione, 8 ml. of pyridine, 2 ml. of water and 0.85 gm. of iodobenzene dichloride. Isolate as in Example 2D, utilizing a 50 gm. silica gel column, and crystallizing from chloroform/ethyl acetate/hexane to obtain the title compound; nmr (dmso-d6) delta 0.83 (C13 –CH3, s), 1.38 (C10 –CH3, s), 4.02 (CH2 –phi, dd), 6.08 (C4 –H, d), 6.15 (C2 –H, dd), 7.65 (C1 –H, d), 7.43 (phi, q).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Schering Corporation; US4183924; (1980); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com