Related Products of 35453-19-1, A common heterocyclic compound, 35453-19-1, name is 5-Amino-2,4,6-triiodoisophthalic acid, molecular formula is C8H4I3NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5-Amino-2,4,6-triiodoisophathalic acid (15.38 g, 27.5 mmol, 1.0 equiv.) was refluxed in SOCl2 ( 10OmL, 1.37 mol, 50.0 equiv.) for 4 hours. The volatiles were removed in vacuo and the resultant dark yellow residue was dissolved in ethyl acetate (300 mL). The organic layer was washed with sat. NaHCO3 (3 x 150 mL), water (3 x 150 mL) and brine (150 mL) and concentrated in vacuo. The residue was dissolve in toluene and passed through a short pad of silica, dried (MgSO4) and concentrated in vacuo to yield the title compound as a beige solid (10.74 g, 66 %). IR spectrum in KBr disc/cm”1: v(N-H) 3370, 3470; V(C=O) 1770, 1798
The synthetic route of 35453-19-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IMPERIAL INNOVATIONS LIMITED; KINGS COLLEGE LONDON; GUYS AND ST THOMAS NHS FOUNDATION TRUST; WO2007/26140; (2007); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com