Electric Literature of 181765-85-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 181765-85-5, name is Methyl 4-chloro-2-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Methyl 4-chloro-2-iodobenzoate (284 mg, 0.96 mmol) is dissolved in DMF (2 mL) then methyl 2-acetamidoacrylate (205 mg, 1 .44 mmol), tetrabutylammonium bromide (308 mg, 0.96 mmol), NaHCO3 (201 mg, 2.39 mmol) and palladium (II) acetate (1 1 mg, 0.05 mmol) are added. The reaction mixture is heated at 85-90 C for 20 h under argon atmosphere. At the begining the reaction mixture is red, but after 10 min turned to dark red. After 20 h the reaction mixture is cooled to rt and 25 mL of water are added. The heterogenous solution is filtered, washed with small portions of water and dried to give the title compound (157 mg, 69%) as a brown solid. 1H-NMR (200 MHz, DMSO-de), delta: 3.86 (s, 3H); 7.41 (s, 1 H); 7.64 (d, 8.8 Hz, 1 H); 8.05 (s, 1 H); 8.20 (d, 8.8 Hz, 1 H). LC-MS: 238 [M+H].
The synthetic route of Methyl 4-chloro-2-iodobenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERZ PHARMA GMBH & CO. KGAA; ABEL, Ulrich; HANSEN, Angela; WOLTER, Falko Ernst; KRUEGER, Bjoern; KAUSS, Valerjans; ROZHKOVS, Jevgenijs; PISKUNOVA, Irena; ZVAGULIS, Artis; TRIFANOVA, Dina; GRUNSTEINE, Ginta; TURE, Anastasija; WO2013/30358; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com