Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, A new synthetic method of this compound is introduced below., COA of Formula: C8H7IO3
A mixture of 5 (846 mg, 3.0 mmol), 11 (869 mg, 5.2 mmol), EDCI (997 mg, 5.2 mmol), HOBt (796 mg, 5.2 mmol), DIPEA (0.89 mL, 5.2 mmol) was dissolved DMF (5 mL) and stirred at room temperature overnight. The reaction was quenched by 1 N of HCl solution and the reaction mixture was extracted with ethyl acetate, neutralized with saturated aqueous NaHCO3 solution, washed with saturated aqueous NaCl solution, dried over anhydrous Na2SO4, and concentrated. The resulting solid was washed with cold methanol to afford 6 (939 g, 2.2 mmol, 73%) as a white solid. This solid compound was pure enough to perform the next step: 1H NMR (400 MHz; CDCl3): delta 9.50 (s, 1H), 8.53 (s, 1H), 7.85 (d, J = 8.2 Hz, 1H), 7.78 (s, 1H), 7.67 (d, J = 8.4 Hz, 2H), 7.07 (d, J = 8.2 Hz, 1H), 6.80 (d, J = 8.4 Hz, 2H), 4.67 (s, 2H), 3.90 (s, 3H); 13C NMR (100 MHz; DMSO) delta 166.5, 166.2, 157.7, 152.0, 138.3, 126.8, 125.7, 122.3, 120.5, 117.7, 114.9, 84.4, 67.2, 52.0; MS (ESI) m/z 428 [M + H]+, 450 [M + Na]+, 466 [M + K]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Nakamura, Hiroyuki; Yasui, Yuka; Ban, Hyun Seung; Journal of Organometallic Chemistry; vol. 747; (2013); p. 189 – 194;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com