202982-67-0, name is 4-Chloro-3-fluoroiodobenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C6H3ClFI
To a solution of 1-chloro-2-fluoro-4-iodobenzene (5.72 g, 22.67 mmol) in 1, 4-dioxane (150 mL) was added 4, 4, 5, 5-tetramethyl-2- (1, 4-dioxaspiro [4.5] dec-7-en-8-yl) -1, 3, 2-dioxaborolane (6.00 g, 22.67 mmol), Pd (dppf) Cl2 (2.47 g, 3.38 mmol) and Cs2CO3 (11.00 g, 33.83mmol) and the mixture was heated at 80 for overnight. Then evaporated the solvent under reduced pressure and the residue was purified by column chromatography (PE: EA = 20: 1) to give product as a clear oil (4.06 g in 67% yield). 1H NMR (DMSO-d6) deltaH 7.51 (t, J= 8.0 Hz, 1H), 7.46 (m, 1H), 7.28 (m, 1H), 7.12-7.20 (m, 1H), 3.91 (s, 4H), 2.51-2.56 (m, 2H), 2.34-2.40 (m, 2H), and 1.80 (t, J = 6.8 Hz, 2H).
The synthetic route of 202982-67-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BEIGENE, LTD.; WANG, Hexiang; GUO, Yunhang; REN, Bo; WANG, Zhiwei; ZHANG, Guoliang; ZHOU, Changyou; (353 pag.)WO2018/54365; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com