Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 811842-30-5, name is 2-Bromo-1-fluoro-4-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 811842-30-5
Into a 1 L four-necked round bottom flask equipped with a stirrer, an Erlin condenser, a nitrogen inlet tube, and a thermometer, 23.2 g (101.8 mmol) of 4-dibenzothiopheneboronic acid of Synthesis Example 9,33.6 g (111.9 mmol) of 3-bromo-4-iodo-1-fluorobenzene of Synthesis Example 23, 340 mL of toluene, 170 mL of ethanol,28.0 g (202.6 mmol) of potassium carbonate and 90 mL of water were placed, and the mixture was stirred at room temperature for 30 minutes under a nitrogen stream.Subsequently, 0.11 g (0.50 mmol) of palladium acetate and 0.30 g (0.98 mmol) of tri (o-tolyl) phosphine were added and heated, followed by stirring at a reflux temperature for 2 hours. The resulting reaction solution was cooled to room temperature, the aqueous layer was separated, and extracted with 150 mL of ethyl acetate. Then, the organic layers were combined, washed with 150 mL of saturated brine, dried with magnesium sulfate, magnesium sulfate was removed by suction filtration, and the solvent was distilled off under reduced pressure. Subsequently, the resulting oil was purified by recrystallization using a mixed solvent of n-heptane and toluene to obtain 18.4 g (yield 53.0%) of the objective compound.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 811842-30-5.
Reference:
Patent; YAMAGATA UNIVERSITY; CHEMIPRO KASEI KAISHA LIMITED; KIDO, JUNJI; SASABE, HISAHIRO; TAKAHASHI, JUN; NAGAI, NAGAI; (723 pag.)JP2018/90561; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com