Reference of 77317-55-6,Some common heterocyclic compound, 77317-55-6, name is Methyl 2-amino-5-iodobenzoate, molecular formula is C8H8INO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 2: Synthesis of methyl 5-iodo-2-(nitro amino) benzoatewherein X is I and R is Me. One hundred g of methyl 2-amino-5-iodobenzoate was dissolved in 1000 ml of acetic acid. Then 100 ml of fuming nitric acid was added to the reaction solution at 150C slowly so that the internal temperature did not exceed 2O0C. The reaction solution was stirred for 30 minutes. Afterwards, 110 ml of acetic anhydride was added to the reaction solution at 2O0C or less, followed by stirring for 1 hour. Then the reaction solution was poured into 2 L of ice water, stirred for 30 minutes, and filtered to obtain 104 g (yield: 90%) of the compound of interest which is in a yellowish solid: 1H NMR (300 MHz, DMSO), delta 8.19 (d, IH, J=2Lambda Hz), 8.07 (dd, IH ,J=8.7, 2.1 Hz), 7.21 (d, IH, J=8.7 Hz), 3.80 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-amino-5-iodobenzoate, its application will become more common.
Reference:
Patent; PHARMACOSTECH CO., LTD.; KIM, Jae Won; CHA, Young Gwan; RYU, Hyung Chul; KIM, Sun Joo; KIM, Sang Hyun; JEON, Tae Hong; WO2010/67912; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com