These common heterocyclic compound, 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1-Iodo-2-(trifluoromethyl)benzene
General procedure: 9-[2-(4-Nitrophenoxy)naphthalene-1-yl]-11,12-dihydro-10H-indeno[6,5,4-kl]xanthene (3a): A mixture of 1a (73.6 mg, 189 mumol, 1.00 equiv.), 2 (67.1 mg, 198 mumol, 1.05 equiv.), Pd(OAc)2 (4.22 mg, 18.8 mumol, 0.10 equiv.), PPh3 (24.7 mg, 94.0 mumol, 0.50 equiv.) and (nBu)4NOAc (341 mg, 1.13 mmol, 6.00 equiv.) in degassed DMF (5 mL) was stirred at 100 ¡ãC for 21 h. The reaction mixturewas filtered through SiO2, flushed with EtOAc and the solvent of the filtrate was removed in vacuo.Column chromatography (SiO2, n-pentane/EtOAc 20:1) yielded 3
The synthetic route of 1-Iodo-2-(trifluoromethyl)benzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tietze, Lutz F.; Eichhorst, Christoph; Heterocycles; vol. 90; 2; (2015); p. 919 – 927;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com