Reference of 77317-55-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 77317-55-6, name is Methyl 2-amino-5-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step 3, Preparation of Methyl 2-(acetoacetylamino)-5-iodobenzoate.; A solution of methyl 2-amino-5-iodobenzoate (17.9 g, 64.6 mmol) and methylacetoacetate (7.0 mL, 64.6 mmol) in toluene (250 mL) was heated to reflux using a Soxhlet extractor filled with 3 angstrom molecular sieves. After 24 h, the molecular sieves were replaced, more methylacetoacetate (3.75 mL, 32.3 mmol) was added, and the solution was refluxed 2 days. Concentration in vacuo and wash with diethyl ether afforded 24.7 g (76%) of methyl 2-(acetoacetylamino)-5-iodobenzoate as an off-white powder. LCMS: Rt = 1.70 min, [MH+362.0].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-5-iodobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2005/118583; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com