Some common heterocyclic compound, 116632-39-4, name is 5-Bromo-2-iodotoluene, molecular formula is C7H6BrI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C7H6BrI
Preparation 49 (4-Bromo-2-methyl-phenyl)-(2-methyl-5-nitro-phenyl)-methanone (compound 449) The reaction was run under an argon atmosphere using dry glassware. 4-Bromo-2-methyliodobenzene (2.40 mL, 16.8 mmol) was dissolved in dry THF (15 mL) and cooled to -60 C. Isopropylmagnesium chloride (2 M in THF, 8.4 mL, 16.8 mmol) was added under stirring during 30 minutes. The reaction mixture was allowed to warm up to -40 C. and the mixture was stirred at -40 C. for 4 h. Compound 401 (4.62 g, 16.8 mmol) was added and the mixture was stirred at -40 C. for 3 h after which it was allowed to warm to room temperature and stirred for 17 h. A saturated aqueous solution of NH4Cl (100 mL) was added and the mixture was stirred for 1 h. The phases were separated and the aqueous phase was extracted with EtOAc (2*100 mL). The combined organic phases were washed with brine, dried (MgSO4), filtered and concentrated in vacuo. The crude product was purified by flash chromatography using CH2Cl2/petroleum ether (40-60) 1:6, 1:4, 1:2 as the eluent to afford the title compound as yellow compound.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 116632-39-4, its application will become more common.
Reference:
Patent; Leo Pharma A/S; US2006/128766; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com