These common heterocyclic compound, 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-Bromo-1-(4-iodophenyl)ethanone
E. i. l-(4-iodophenyl)-2-morpholinoethan-l-one: 2-bromo-l-(4-iodo-phenyl)-ethanone (3.8 g; 11.7 mmol) was dissolved in DCM (100 mL). Morpholine (2.02 mL; 23.4 mmol) was added and the reaction mixture was stirred for 2 h. The reaction mixture was washed with water (50 mL). The evaporation residue was purified by CC (Hept-EA) to give the title product as a light yellow solid (3.3 g; 85% yield). XH NMR (i/tf-DMSO) delta: 7.93-7.90 (m, 2H); 7.76-7.73 (m, 2H); 3.81 (s, 2H); 3.58-3.55 (m, 4H); 2.52-2.47 (m, 4H). MS (ESI, m/z): 331.87 [M+H+] for Ci2H14N04I; tR = 0.53 min.
The synthetic route of 2-Bromo-1-(4-iodophenyl)ethanone has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BLUMSTEIN, Anne-Catherine; CHAPOUX, Gaelle; JACOB, Loic; MASSE, Florence; MIRRE, Azely; PANCHAUD, Philippe; SCHMITT, Christine; SURIVET, Jean-Philippe; (194 pag.)WO2017/37221; (2017); A1;,
Iodide – Wikipedia,
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