In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19821-80-8 as follows. Recommanded Product: 1,3-Dibromo-2-iodobenzene
General procedure: 10.0 grams (g) (27.6 millimoles, mmol) of 1,3-dibromo-5-iodobenzene, 4.06 g (27.6 mmol) of (2-cyanophenyl)boronic acid, 1.60 g (1.38 mmol) of tetrakis(triphenylphosphine)palladium(0) (Pd(PPh3)4), and 9.55 g (69.1 mmol) of potassium carbonate were added to a mixed solution containing 60 milliliters (mL) of tetrahydrofuran (THF) and 30 mL of water, and the reaction mixture was stirred for 12 hours under reflux. After the reaction was completed, the reaction product was cooled to room temperature, and the aqueous solution layer was removed therefrom through extraction. The resultant obtained therefrom was filtered through a silica gel under reduced pressure, and the filtrate was concentrated under reduced pressure. The product obtained therefrom was separated by silica gel column chromatography to provide Intermediate (A) (4.38 g, yield of 47%).
According to the analysis of related databases, 19821-80-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Samsung Electronics Co., Ltd.; Samsung SDI Co., Ltd.; JUNG, Yongsik; JEON, Soonok; KWON, Eunsuk; KIM, Sangmo; KIM, Juhyun; SON, Jhunmo; CHUNG, Yeonsook; KIM, Joonghyuk; (327 pag.)US2020/31812; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com