Adding a certain compound to certain chemical reactions, such as: 61203-48-3, name is 2-Iodo-4,5-dimethoxybenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61203-48-3, HPLC of Formula: C9H9IO4
[C.] [N- (6-NITROCINNOLIN-4-YL)-N- (N, N-DIMETHYLAMINOETHYL)-2-IODO-4,] 5- dimethoxybenzamide [(LLA).] Oxalyl chloride (3.0 g, 23.2 mmol) was added to a mixture of 2-iodo-4, 5-dimethoxybenzoic acid (1.5 g, 4.9 mmol) in methylene chloride (40 mL), and the stirred mixture was heated to reflux under nitrogen for 4 h. The mixture was concentrated under reduced pressure and the acid chloride was redissolved in methylene chloride (40 mL) and added to a mixture [OF 10A] (1.0 g, 4.0 mmol) and TEA (2.5 g, 25.0 mmol) in methylene chloride (40 mL). The resulting mixture was heated to reflux overnight and then cooled and washed with saturated sodium bicarbonate (3 x 100 mL) and brine (150 mL), dried [(MGS04)] and evaporated, and the residue was chromatographed in 99: 1 [CHC13-MEOH] to provide 590 mg as a glue, in 29% yield; IR (CHCl3) 1654 [; 1H] NMR (CDC13) [6] 2.11 (s, 6H), 2.58 (m, 2H), 3.40 (s, 3H), 3.64 (s, 3H), 3.85 (m, 1H), 4.16 (m, [1H),] 6.51 (s, 1H), 6. 85 (s, [1H),] 8. 50 (m, [1H),] 8.60 (m, [1H),] 9.28 (s, 1H), 9.61 (m, 1H) ; 13C NMR [(CDC13)] [6] 45.2, 48.1, 52.3, 56.2, 57.0, [82.] 5, 111.3, 121.0, 121.7, 123.8, 124.3, 131.0, 132.7, 138.2, 145.8, 148. 8,148. 0, 150.2, 151.4, 169.6 ; HRMS calcd for [C2LH23IN505H :] 552.0744 ; found: 552.0743.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Iodo-4,5-dimethoxybenzoic acid, and friends who are interested can also refer to it.
Reference:
Patent; RUTGERS, THE STATE UNIVERSITY; LAVOIE, Edmond, J.; RUCHELMAN, Alexander, L.; LIU, Leroy, F.; WO2004/14906; (2004); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com