Application of 173406-17-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 173406-17-2, name is tert-Butyl 3-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 8B; tert-Butyl 3-[N-(3-Chloro-4-methoxyphenyl)-pyridin-3-ylmethylamino] benzoate; To a solution of 3-chloro-4-methoxyphenyl-N- (3-pyridylmethyl) amine (248 mg, 1 mmol) and t- butyl 3-iodobenzoate (450 mg, 1.5 mmol) in 10 mL toluene was added NaOtBu (150 mg, 1.5 mmol), Pd2dba3 (18 mg, 0.02 mmol), and P (tBu) 3HBF4 (12 mg, 0.04 mmol). The mixture was stirred overnight then filtered through celite and loaded onto a silica column (12g). The product was eluted with a linear gradient from 30% to 45% EtOAc in hexanes to give tert-Butyl 3-[N-(3- Chloro-4-methoxyphenyl)-pyridin-3-ylmethylamino] benzoate as a yellow oil.
The synthetic route of tert-Butyl 3-iodobenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2005/61458; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com