Reference of 216393-67-8, A common heterocyclic compound, 216393-67-8, name is 4-Chloro-2-fluoro-6-iodoaniline, molecular formula is C6H4ClFIN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 20 mL dehydrated deoxygenated Schlenk tube, acetophenone p-toluenesulfonylhydrazone(0.30 mmol, 86.4 mg), 4-chloro-2-fluoro-6-iodoaniline (0.2 mmol, 54.2 mg), bistriphenylphosphine(0.02 mmol, 14.0 mg), sodium tert-butoxide (1.2 mmol, 115.2 mg) 3.0 mL diethylene glycol dimethyl ether (diglyme), and finally 0.1 MPa of CO2 was injected into the reaction tube. The sealed reaction tube was heated and stirred in an oil bath at 140 C for about 24 hours Rear. The reaction solution was acidified with 1.5 mL of a 1 M hydrochloric acid solution and extracted with ethyl acetate (4 mL x 5) The organic phases were combined and finally the product was purified by column chromatography and then dried to give 29.5 mg of a white solid powder as a solid54%.
The synthetic route of 216393-67-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Changzhou University; Sun, Song; Cheng, Jiang; Hu, Weiming; Gu, Ning; Wang, Bingbing; (12 pag.)CN106432074; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com