5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C7H5IO2
Under an argon atmosphere,5-iodo-1,3-benzodioxole (2.09 mL, 15.0 mmol), 4-bromoaniline (1.03 g, 6.0 mmol) synthesized in Reference Example 1 was charged in a 50 mL flask with a Dean Stark. 00 mmol),1,10-phenanthroline (108 mg, 0.60 mmol),Copper iodide (114 mg, 0.60 mmol) and potassium hydroxide (5.39 g, 96.0 mmol) were taken, toluene (30 mL) was added, and the mixture was heated under reflux at 125 C. for 16 hours. After standing to cool, chloroform was added to the reaction mixture, followed by filtration through silica gel. The filtrate was concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (elution solvent: hexane / chloroform = 2/1) to obtain the objective N, N-bis (1,3-benzodioxole -5-yl) -4-bromoaniline as a brown viscous solid (1.44 g, 3.49 mmol, 51%).
The synthetic route of 5876-51-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TOSOH CORPORATION; SAGAMI CHEMICAL RESEARCH INSTITUTE; AIHARA, HIDENORI; (45 pag.)JP2015/163597; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com