Reference of 626-62-0, These common heterocyclic compound, 626-62-0, name is Iodocyclohexane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: THF (1.5 mL), organic halide 3 (1.5 mmol, 1.0 equiv) and Ir(dtbbpy)(ppy)2 PF6 (3.5 mg, 0.0025 equiv) were successively added to a test tube containing Zn dust (73 mg, 1.125 mmol, 0.75 equiv). The reaction mixture was stirred under irradiation with a strip of 400 nm LEDs for 5 h, with water cooling to maintain the reaction temperature around 23-25 C. For the work-up, H2O (5 mL) was added and the mixture was extracted with hexane (3 ¡Á 7 mL). The combined extracts were filtered through Na2SO4 and concentrated under vacuum.The residue was purified by flash chromatography eluting with hexane/EtOAc.
The synthetic route of 626-62-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Levin, Vitalij V.; Agababyan, Daniil P.; Struchkova, Marina I.; Dilman, Alexander D.; Synthesis; vol. 50; 15; (2018); p. 2930 – 2935;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com