Related Products of 26059-40-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26059-40-5, name is 2-(2-Iodophenyl)ethan-1-ol belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
(1) weighing 2-iodo-phenethyl alcohol 1.0g in 100mL single-necked flask,Join 20mL THF room temperature stirring to dissolve,2.8 g of di-tert-butyl azodicarboxylate and 3.2 g of triphenylphosphine solid were sequentially added,The reaction was stirred at room temperature for 1.5h,The reaction solution was washed once with 20 mL of 1 mol / L diluted hydrochloric acid,20mL saturated sodium bicarbonate once, 20mL saturated brine once,The organic phase is dried over anhydrous magnesium sulphate, filtered and the filtrate is removed by rotary evaporation to give 5.8 g of crude product. The crude product was purified by column chromatography on silica gel eluting with PE: EA = 20: 1 to give 1.6 g of a white solid,Namely N, N’-di-tert-butoxycarbonyl-2-iodophenethylhydrazine,Yield86%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Iodophenyl)ethan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Wuxi Jiehua Pharmaceutical Technology Co., Ltd.; Gou Yuancheng; (7 pag.)CN107033090; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com