Adding a certain compound to certain chemical reactions, such as: 612-55-5, name is 2-Iodonaphthalene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 612-55-5, Formula: C10H7I
5-(2-(Naphthalen-l-yl)thiophen-3-yl)-2-trityl-2//-tetrazole A solution of 5-(2- (tributylstannyl)thiophen-3-yl)-2-trityl-2H-tetrazole (2.73 g, 4.0 mmol), 2-iodonaphthalene (0.88 mL, 6.0 mmol), Pd(PPh3)4 (139 mg, 0.12 mmol) and CuI (45.6 mg, 0.24 mmol) in 12 mL of DMF was heated to 60 0C under argon overnight. The reaction was cooled to room temperature, quenched with saturated H2O, and extracted with EtOAc. The organic phase was dried over anhydrous MgSO4 and concentrated. The residue was purified by flash chromatography (hexane: CH2Cl2: ether = 50: 25: 3). 1.73 g (83 %) of product was obtained as a white solid.
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Reference:
Patent; MCMASTER, Christopher, R.; WEAVER, Donald; DENOVAMED INC.; BARDEN, Christopher, J.; HENNEBERRY, Annette, L.; BYERS, David M.; WO2008/128321; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com