Application of 148870-57-9, The chemical industry reduces the impact on the environment during synthesis 148870-57-9, name is 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one, I believe this compound will play a more active role in future production and life.
From 11 g of that product, 3.3 g of LiAlH4 and 160 ml of tetrahydrofuran heated at reflux for 6 hours, 7 g of N-[(4-methoxybenzocyclobut-1-yl)methyl)-N-(methyl)amine (yield 90%) are obtained. From 15 g of 7,8-dimethoxy-3-[3-iodopropyl]-1,3-dihydro-2H-3-benzazepin-2-one, 7 g of N-[(4-methoxybenzocyclobut-1-yl)methyl]-N-(methyl)amine, 22 g of K2 CO3 and 300 ml of acetone, there are obtained 17.5 g (theoretical yield) of 7,8-dimethoxy-3-{3-{N-[(4-methoxybenzocyclobut-1-yl)-methyl)-N-(methyl)amino}propyl}-1,3-dihydro-2H-3-benzazepin-2-one. From 5 g of that product, 60 ml of ethanol, 1 ml of acetic acid and 3 g of palladium hydroxide, there are obtained 1.9 g of 7,8-dimethoxy-3-{3-{N-[(4-methoxybenzocyclobut-1-yl)methyl]-N-(methyl)amino}propyl}-1,3,4,5-tetrahydro-2H-3-benzazepin.-2-one (yield: 65%), which is converted into the corresponding dihydrochloride which, recrystallized from acetonitrile, melts at 160-164 C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Adir et Compagnie; US5296482; (1994); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com