Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 260355-20-2, name is 1-Chloro-4-iodo-2-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., Safety of 1-Chloro-4-iodo-2-(trifluoromethyl)benzene
[Reference Example 1] 4-chloro-3-trifluoromethyl-1-(1-trifluoromethylethenyl) benzene In a nitrogen atmosphere, to 53 mL of a 1M tetrahydrofuran solution of 1-trifluoromethylethenyl zinc bromide prepared according to a method described in the literatures, 7.1 g of 2-chloro-5-iodobenzotrifluoride and 0.65 g of dichlorobis(triphenylphosphine) palladium (II) were added and the resultant mixture was stirred while heating the mixture to reflux for 2.5 hours. After the completion of the reaction, the reaction mixture was left to be cooled down to room temperature and 200 mL of hexane was added to the reaction mixture, followed by filtering off the deposited insoluble substance. The resultant filtrate was washed with water (50 mL*1) and then dehydrated and dried over saturated saline and anhydrous sodium sulfate in this order and the solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography eluding with hexane to obtain 4.8 g of the objective substance as a colorless oily substance. 1H NMR (CDCl3, Me4Si, 300 MHz) delta 7.75 (s, 1H), 7.57 (d, J=8.8 Hz, 1H), 7.54 (d, J=8.8 Hz, 1H), 6.08 (s, 1H), 5.84 (s, 1H).
The synthetic route of 260355-20-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nissan Chemical Industries, Ltd.; EP2199287; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com