Month: January 2021

Adding a certain compound to certain chemical reactions, such as: 35674-27-2, name is 4-Iodo-3-nitrobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35674-27-2, name: 4-Iodo-3-nitrobenzoic acid

b) 4-Iodo-3-nitro-benzoic acid methyl ester A methanolic solution of 4-iodo-3-nitro-benzoic acid (10.0 g, 34.13 mmol, 1 eq. ) was treated with concentrated sulfuric acid (7 mL) and the reaction heated to reflux. After 6 hours, the acid was neutralized with solid sodium bicarbonate and the methanol removed in vacuo. The residual oil was diluted with water and extracted with diethyl ether. Combined the organics, washed with brine, dried, filtered, and removed the solvent in vacuo leaving an orange oil which was purified via normal phase chromatography to leave 4-iodo-3-nitro-benzoic acid methyl ester (8.08 g, 77% yield) as a yellow solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/40157; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 21304-38-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21304-38-1, name is 4-Iodobenzene-1,2-diamine belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

4-iodo-1,2-phenylenediamine (2 g, 1 eq), 4-dimethylaminonitrozoaniline (1.26 g, 1 eq) and NaOH (340 mg, 1 eq) were mixed neat and heated at 70 C. for 20 min with constant triturating. The resulting paste was extracted with toluene, concentrated in vacuum and purified by flash chromatography (SiO2, hexane/AcOEt, 8/2) giving a mixture of two isomers (3 and 4 iodo) as a red solid in 32% yield; 4-iodo-1,2-phenylenediamine (2 g, 1 eq), 4-dimethylaminonitrozoaniline (1.26 g, 1 eq) and NaOH (340 mg, 1 eq) were mixed neat and heated at 70 C. for 20 min with constant triturating. The resulting paste was extracted with toluene, concentrated in vacuum and purified by flash chromatography (SiO2, hexane/AcOEt, 8/2) giving a mixture of two isomers (3 and 4 iodo) as a red solid in 32% yield.

The synthetic route of 4-Iodobenzene-1,2-diamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tamagnan, Gilles D.; Alagille, David; Costa, Herve Da; US2007/258887; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6940-76-7, name is 1-Chloro-3-iodopropane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 1-Chloro-3-iodopropane

335 mg (1.30 mmol) of 4-(3,4-difluorophenyl)phthalazin-1(2H)-one (8n) was dissolved in 10 ml of N,N-dimethylformamide, and 62 mg (1.56 mmol) of sodium hydride were added at 0oC. After being stirred for 30 min, 0.21 ml (1.95 mmol) 3-iodo-1-chloropropane was then added to reaction mixture. After being stirred for 1 h, the reaction mixture was combined with 50 ml of water and extracted with ethylacetate (50 ml X 2) being washed with water and a sodium hydroxide solution, and then the combined organic layer was dried over anhydrous sodium sulfate, and filtered. The solvent was removed from the filtrate under a reduced pressure, and the resulting residue was refined by silica gel column chromatography (ethyl acetate : n-hexane = 1 : 3) to obtain 400 mg (yield 92%) of the title compound.

The synthetic route of 6940-76-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lim, Chae Jo; Kim, Soo Hee; Lee, Byung Ho; Oh, Kwang-Seok; Yi, Kyu Yang; Bioorganic and Medicinal Chemistry Letters; vol. 22; 1; (2012); p. 427 – 430;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 54413-93-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54413-93-3, name is 2-Iodo-5-methoxybenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: NaIO4 (6.7 g, 31 mmol, 1.0 equiv) and2-iodobenzoic acid (7.4 g, 30 mmol, 1.0 equiv) were suspended in 30% (v:v) aqueousacetic acid (45 mL). The reaction mixture was vigorously stirred and refluxed for 3 hprotecting from light. Cold water (120 mL) was then added and allowed to cool toroom temperature. After 1 h, the crude product was collected by filtration, washedwith ice water (3 x 30 mL) and acetone (3 x 30 mL). After air-drying in the dark,hydroxybenziodoxole 2 was yielded as a white solid.

The synthetic route of 2-Iodo-5-methoxybenzoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Article; Pan, Yue; Jia, Kunfang; Chen, Yali; Chen, Yiyun; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 1215 – 1221;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7681-82-5, name is Sodium iodide, A new synthetic method of this compound is introduced below., Application In Synthesis of Sodium iodide

General procedure: A typical example is exemplified by the synthesis of 4b: To a stirred solution of TMEDA (1.36 mL,9 mmol) in hexane (5 mL) was added dropwise at ice bath temperature n-butyllithium (9 mmol) in hexane followed by acetophenone trimethylsilyl enol ether 1 (576 mg, 3 mmol), and the mixture was stirred for 24 h at room temperature. In a separate flask, a mixture of bismuth(III) chloride (315.5 mg,1 mmol) and tris(4-methylphenyl)bismuthane (964 mg, 2 mmol) was stirred in ether (10 mL) at room temperature for 1 h. To the suspension of chlorobis(4-methylphenyl)bismuthane (ca. 3 mmol) thus formed was added sodium iodide (450 mg, 3 mmol) and a few drops of 15-crown-5 ether and the resulting yellowish mixture was stirred for 3 h at room temperature. To a suspension of the lithium compound previously prepared was added at room temperature magnesium dibromide diethyl etherate (775 mg, 3 mmol) followed by, at -30 C, a suspension of iodobis(4-methylphenyl)bismuthane(ca. 9 mmol), and the resulting mixture was stirred for 1 h, during which time the temperature was raised to ambient temperature. The reaction mixture was poured into brine (50 mL) and extracted with ethyl acetate (50 mL ¡Á 3). The combined extracts were concentrated to leave an oily residue, which was purified by chromatography (silica gel) using hexane-ethyl acetate (5:1) as the eluent to afford 4b in 30% yield (459 mg, 0.9 mmol). Because 4a, 4f and 10 underwent decomposition when purified by chromatography on silica gel, these compounds were converted into the corresponding halobismuthanes 5a, 5f and 11, respectively, without isolation.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Murafuji, Toshihiro; Tomura, Mai; Ishiguro, Katsuya; Miyakawa, Isamu; Molecules; vol. 19; 8; (2014); p. 11077 – 11095;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, molecular formula is C6H3BrINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H3BrINO2

Under the protection of argon, 1-naphthalene boronic acid (22.0 g, 128.1 mmol), 4-bromo-1-iodo-2-nitrobenzene (35.0 g, 106.8 mmol) and Na2CO3 (34.0 g, were sequentially added to the reaction flask. 320.4 mmol), tetrakistriphenylphosphine palladium (6.17 g, 5.3 mmol), toluene (640 ml) and ethanol (160 ml), and the mixture was stirred at 90 C for 3 hours. After the stirring was completed, distilled water (160 ml) was poured, and the mixture was cooled to room temperature, the organic phase was extracted with ethyl acetate, and the organic phase was concentrated to give compound B1 (30 g, 86%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 112671-42-8, its application will become more common.

Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Zhou Wenting; Cai Hui; (39 pag.)CN108822020; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 340825-13-0,Some common heterocyclic compound, 340825-13-0, name is 6-Iodo-3,4-dihydronaphthalen-1(2H)-one, molecular formula is C10H9IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 8B: (S)-N-(6-Iodo-3,4-dihydronaphthalen-1(2H)-ylidene)-2-(methoxymethyl) pyrrolidin-1-amine To a stirred mixture of 6-iodo-3,4-dihydronaphthalen-1(2H)-one (I-8A, 20.90 g, 77 mmol), p-toluenesulfonic acid monohydrate (0.584 g, 3.07 mmol), and cyclohexane (40 mL) was added (S)-2-(methoxymethyl)pyrrolidin-1-amine (10 g, 77 mmol) dropwise at room temperature under nitrogen. The mixture was heated with azeotropic removal of water for 5 h. The reaction mixture was diluted with ethyl acetate (20 mL) and mixed with saturated aqueous sodium bicarbonate solution (15 mL). The aqueous layer was separated and extracted with ethyl acetate (2*30 mL). The combined organic solutions were dried over anhydrous sodium sulfate and concentrated under reduced pressure. Flash chromatography purification (330 g silica gel column, gradient elution from 0% to 20% EtOAc in hexanes) afforded (S)-N-(6-iodo-3,4-dihydronaphthalen-1(2H)-ylidene)-2-(methoxymethyl)pyrrolidin-1-amine (29.1 g, 76 mmol) as a yellow liquid. LC/MS M+1=385.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Iodo-3,4-dihydronaphthalen-1(2H)-one, its application will become more common.

Reference:
Patent; Dhar, T. G. Murali; Xiao, Hai-Yun; Dyckman, Alaric J.; Chan, Eric J.; Dabros, Marta; Roberts, Daniel Richard; US2014/235591; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Iodo-2-(trifluoromethyl)benzene

General procedure: A mixture of aryl iodide (2 mmol), CuI (0.10 mmol), ligand(1.1 mmol), and S8 (1.1 mmol) were added to an oven-driedreaction tube equipped with a septum. The reaction tube wasevacuated and back-filled with argon. Under a counterflowof argon, EIPA (0.258 g, 2 mmol) and DMSO (2 mL) wereadded, and the mixture stirred at r.t. for 8 h. After completedisappearance of aryl iodide (monitored by TLC), H2O (5mL) was added, and the mixture was extracted with CH2Cl2(3 ¡Á 5 mL). The combined organic phases were dried (onMgSO4) and filtered before evaporation of the solvent. Theresidue was purified on silica gel, eluting with PE?EtOAc(20:1), to give product 2. Analytical and spectroscopic datafor all derivatives, except 2g?i have been reported previously.19

The synthetic route of 444-29-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yavari, Issa; Ghazanfarpour-Darjani, Majid; Solgi, Yazdan; Synlett; vol. 25; 8; (2014); p. 1121 – 1123;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 144550-76-5, name is Methyl 2-amino-4-iodobenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 2-amino-4-iodobenzoate

e. Dimethyl 7-iodo-4-hydroxyquinoline-2,3-dicarboxylate Using a procedure similar to that described in Example 3c. except starting with methyl 2-amino-4-iodobenzoate, the crude title diester was obtained as a green solid (2.6 g, 92%). This material was purified by chromatography over silica gel (eluant: methylene chloride/methanol; 9.5/0.5) to provide the title compound (0.85 g, 30%) as a tan solid, mp 243-244 C.; MS(CI): 388 (M+H). Analysis for C13 H10 INO5: Calculated: C, 40.33; H, 2.60; N, 3.62 Found: C, 40.26; H, 2.77; N, 3.54

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Imperial Chemical Industries, PLC; US5599814; (1997); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 82998-57-0,Some common heterocyclic compound, 82998-57-0, name is 3-Iodo-4-methylbenzoic acid, molecular formula is C8H7IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-iodo-4-methylbenzoic acid (3.2 g, 12.2 mmol) was dispersed in 50 mL of thionyl chloride.The reaction system was heated to 82 C, kept under reflux for 1 hour, and cooled to room temperature.The reaction solution was added to 50 mL of toluene while maintaining slow stirring.Concentrate under reduced pressure to a pale yellow oil.After the concentrate was dissolved in 100 mL of dichloromethane,To this solution was added 3-trifluoromethylaniline (2.3 mL, 18.3 mmol) and diisopropylethylamine (9 mL).The reaction system was stirred at room temperature overnight to precipitate a large amount of white solid.The reaction solution was concentrated under reduced pressure and then evaporated.Washed with saturated ammonium chloride solution and saturated brine,The organic phase was dried over anhydrous magnesium sulfate and concentrated.Purification by silica gel column chromatography to obtain compound 8(3.5 g, 71%) was obtained as a white solid.

The synthetic route of 82998-57-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenzhen Ruixi Biological Technology Co., Ltd.; Jiao Zhaodong; Li Xitao; Tao Guanyu; Pan Zhengying; (36 pag.)CN109305944; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com