Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52807-27-9, name is 4-Chloro-2-iodoanisole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H6ClIO
Example 5: Synthesis of 1-BICYCLO [2.2. 1] hept-5-en-2-ylmethyl-4- (5-chloro-2-methoxy-phenyl)-2-methyl-piperazine. CH3 Pd2dba3 1 I N (+)-BINAP OMe CNH NaBH (OAc) 3 OMe N I C 3 18-crown-6 SN QCH3 y’J”3 i J N NaOt-Bu/THF H pwave, 80 OC 5 mine [0102] 10 mg (0. 010 eq) PD2DBA3-CHC13, 9. 0 mg (0.015 eq) racemic BINAP, 135 mg (1.4 eq) NAOT-BU, 370 mg (1.4 eq) 18- crown-6 ether and 1.0 mL anhydrous tetrahydrofuran were combined in a microwave vial. 268 mg (1.0 EQ, 1. 0 mmol) 4-Chloro-2- IODOANISOLE was added, followed by 120 mg (1.2 eq) racemic 2- methylpiperazine. The vial was flushed with nitrogen prior to being microwaved at 80C for 5 minutes. The reaction mixture was diluted with 1.0 mL DMSO: methanol (1 : 1) and centrifuged (4, 000 rpm, RT, 8 min). The supernatant was filtered and purified by reverse-phase HPLC (2-99% CH3CN in 0. 085% TFA (AQ), 50 ML/MIN, 2.0 mL injected). Yield = 50 mg (14%) of a light brown oil (isolated as the mono-TFA salt); [0103] 1H-NMR (400 MHZ, DMSO-D6) No. 9.14 (br d, J = 8.6 Hz, 1H), 8. 71 (br d, J = 7.8 HZ, 1H), 7. 10 (dd, J = 8.7 HZ, 2. 4 HZ, 1H), 6. 99 (d, J = 8.8 HZ, 1H), 6. 94 (d, J = 2.5 HZ/1H)/3. 80 (S, 3H), 3. 42 (br M, 4H), 3. 17 (M, 1H), 2. 85 (M, 1H), 2. 72 (M, 1H), 1. 25 (d, J = 6.4 HZ, 3H) ; LC/MS retention time (10-99% CH3CN/0. 05% TFA gradient over 5 min): 1.82 min; Theoretical (M+H) + m/z = 241. 1; Found 241.2.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52807-27-9.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2005/30188; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com