Adding a certain compound to certain chemical reactions, such as: 689291-89-2, name is 5-Bromo-2-iodobenzaldehyde, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 689291-89-2, COA of Formula: C7H4BrIO
Compound 12 (32 mg, 0.10 mmol), 41 (55.6 mg, 0.103 mmol), PdCl2(PPh3)2 (3.6 mg, 0.0051 mmol), and CuI (1.96 mg, 0.0103 mmol) were added to Et3N (6 mL). The solution was bubbled with N2 at rt for 5 min and then stirred at rt under N2 protection for 3 h. After the reaction was completed as checked by TLC analysis, the solvent was removed by rotary evaporation. The resulting residue was diluted with CHCl3. The mixture was filtered through a MgSO4 pad. The solution obtained was sequentially washed with HCl (aq 10%) and brine. The organic layer was dried over MgSO4 and concentrated under vacuum to give crude 51, which was further purified by silica flash column chromatography (hexanes/CH2Cl2, 7:3) to yield compound 51 (60 mg, 0.083 mmol, 81%) as a white solid. Mp 82-83 C; IR (KBr) 2918, 2851, 2207, 1690, 1631, 1603, 1583, 1552, 1533, 1513, 1497, 1469, 1420 cm-1; 1H NMR (CDCl3, 500 MHz) delta 10.66 (s, 1H), 8.07 (d, J=1.5 Hz, 1H), 7.69 (dd, J=8.0, 1.5 Hz, 1H), 7.64 (d, J=8.5 Hz, 2H), 7.60 (d, J=8.5 Hz, 2H), 7.49 (d, J=8.0 Hz, 1H), 7.02 (s, 1H), 7.01 (s, 1H), 4.05-4.01 (m, 4H), 1.89-1.83 (m, 4H), 1.60-1.46 (m, 4H), 1.30-1.26 (m, 24H), 0.89-0.86 (m, 6H); 13C NMR (CDCl3, 125 MHz) delta 190.9, 154.3, 154.0, 137.2, 136.8, 134.3, 132.24, 132.20, 130.3, 128.5, 125.9, 123.4, 118.7, 116.7, 116.4, 114.1, 113.5, 111.8, 94.3, 93.8, 90.5, 90.2, 69.8, 69.6, 32.1, 29.9, 29.82, 29.76, 29.6, 29.5, 29.4, 26.3, 22.9,14.3; HRMS (CI) m/z calcd for C44H52BrNO3 721.3131, found 722.3139 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-2-iodobenzaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Zhou, Ningzhang; Wang, Li; Thompson, David W.; Zhao, Yuming; Tetrahedron; vol. 67; 1; (2011); p. 125 – 143;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com