Application of 723294-75-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 723294-75-5 name is 3-Fluoro-5-iodobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Procedure for preparation of compound 2:To a solution of 13 (1000mg, 0.46mmoi) and 14 (135.8mg, 0.SSmmoi) in DMSO (2OmL) was added CuT (95mg, 0.OSmmol) and C52C03 (399.7mg, 0.92mmoi) at rt, the mixture was stirred at 100C for lOh under N2 atmosphere. The solution was diluted with EtOAc (lOmL), washedwith water, biine (iOmnL), dried over anhydrous Na2SO4, filtered and concentrated to dryness. The residue was purified by prep-TLC to afford the target product Compound 2 (5.0mg, yield:3.2 % LCMS: m/z, 338.0 ?M+H)1INNIR (400 MHz, CDCI3): .59 (d, j:::: 4.4 Hz, 111), 7.88 (d, j:::: 6.8 Hz, 1H), 759-752(m, 3H), 750-745 (m, 3H), 7.32-7.28 (m, 3H), 7.19-7.17 (m, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Fluoro-5-iodobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; LI, Yongguo; (44 pag.)WO2017/173604; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com