Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 755027-18-0, name is 1-Bromo-4-iodo-2-methoxybenzene, A new synthetic method of this compound is introduced below., COA of Formula: C7H6BrIO
To a stuffed solution of 1-bromo-4-iodo-2-methoxybenzene (2.4 g, 7.66 mmol) in diethyl ether (25 mL) was added n-BuLi (2M in hexane; 4.40 mL, 8.81 mmol) at -78 C dropwise. The reaction mixture was stuffed at -78 C for 30 mm, and then triisopropyl borate (2.03 mL, 8.81 mmol) was slowly added to the reaction mixture at -78 C. The temperature of the reaction mixture was gradually raised to RT over a period of 1 h, and then the reaction mixture was stirred at RT for 30 mm. After 30 mm, 3 N HC1 (25 mL) was slowly added to the reaction mixture at 0 C and stuffed for 1 h. The progress of reaction was monitored by TLC. After completion of reaction, the reaction mixture was diluted with water (150 mL) and the product was extracted with EtOAc (2×200 mL). The combined organic layers were washed with brine (100 mL), dried over sodium sulfate and concentrated. The residue obtained was triturated with hexane (2×25 mL) to afford 4-bromo-3-methoxyphenylboronic acid as an off-white solid (1.45 g).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; RAI, Roopa; CHAKRAVARTY, Sarvajit; GREEN, Michael, John; PHAM, Son, Minh; PUJALA, Brahmam; AGARWAL, Anil, Kumar; NAYAK, Ajan, Kumar; KHARE, Sweta; GUGULOTH, Rambabu; RANDIVE, Nitin, Atmaram; WO2015/58084; (2015); A1;,
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