Electric Literature of 1878-69-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1878-69-9, name is 2-(3-Iodophenyl)acetic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a stirred solution of 9 (60 mg, 0.34 mmol) in DMF (3 mL) HOBt (60 mg, 0.35 mmol) and EDC (68 mg, 0.35 mmol) were added at 0 C. The mixture was stirred at 0 C for 15 min and at room temperature for 1 h. Then, 4-tert-butylaniline (64 L, 0.40 mmol) was added, and the mixture was stirred at room temperature overnight. The mixture was diluted with brine and extracted with AcOEt. The organic phase was washed with 2 N HCl solution, saturated NaHCO3, and brine, dried (NaSO4), and evaporated under vacuum. The residue (105 mg) was chromatographed on silica gel (6 g) using petroleum ether/AcOEt = 93/7 as eluent to give 80 mg (77%) of 4a.
The synthetic route of 2-(3-Iodophenyl)acetic acid has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ortar, Giorgio; Morera, Ludovica; Schiano Moriello, Aniello; Morera, Enrico; Nalli, Marianna; Di Marzo, Vincenzo; De Petrocellis, Luciano; Bioorganic and Medicinal Chemistry Letters; vol. 22; 10; (2012); p. 3535 – 3539;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com