Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51839-15-7, name is Dimethyl 5-iodoisophthalate, A new synthetic method of this compound is introduced below., Product Details of 51839-15-7
To a 500 mL three-necked flask was added 100 g, 312 mmolOf 5-iodoisophthalic acid dimethyl ester,3.50 g, 16 mmol of NiBr2 and 300 ml of triethyl phosphite. After vacuuming three times,The temperature was gradually raised to 160 C under magnetic stirring, and the temperature was raised to 175 C after 4 hours of reaction. After 10 hours of continuous reaction,The diethyl phosphonate diethyl isophthalate was obtained by distillation under reduced pressure. Thereafter, 20 g of diethyl phosphonate diethyl isophthalate was weighed,With 50ml concentrated hydrochloric acid 120 degrees Celsius reaction 10h, cooled to room temperature filtration,To obtain a phosphonic acid substituted isophthalic acid. Finally, the phosphonic acid-substituted isophthalic acid was reacted with thionyl chloride under reflux conditions for 12 h,Get the target product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Chinese Academy Of Sciences Changchun Applied Chemistry Institute; Zhang Suobo; Zhao Yali; Zhang Zhiguang; Li Shenghai; Dai Lei; (19 pag.)CN107176963; (2017); A;,
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