Synthetic Route of 116632-39-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 116632-39-4, name is 5-Bromo-2-iodotoluene, This compound has unique chemical properties. The synthetic route is as follows.
A Schlenk tube was charged with compound 471 (4.25 G, 10.9 MMOL) in 1,4-dioxane (40 mL), 5-BROMO-1-IODO-TOLUENE (3. 88 G, 13.1 MMOL), CS2CO3 (4.97 G, 15.26 MMOL), PD2 (dba) 3 (250 mg, 0.27 MMOL), and rac-BINAP (255 mg, 0.41 MMOL). The tube was capped with a rubber septum, flushed with argon for 5 min, and then stirred at 100 C for 72 h. The reaction mixture was allowed to cool to RT, and then poured into a mixture of water and EtOAc. The aqueous phase was extracted twice with more EtOAc. The combined organic phases were washed with brine, dried (MGSO4), filtered and concentrated in vacuo. The crude product was purified by chromatography eluting with petroleum ether/EtOAc 4: 1 to afford the title compound as YELLOW FOAM. 1H NMR (CDOS) 8 7.39 (d, LH), 7. 35 – 7.25 (m,3H), 7.14 (d,1H), 6.81 (m,2H), 6.69 (m,2H), 5.63 (BS, LH), 4.70 (bt, LH), 4.23-4. 00 (m, 3H), 3.95-3. 77 (m, 2H), 3.53 (m, LH), 2. 51 (s, 3H), 2. 23 (s, 3H), 1.92-1. 45 (m, 6H)
The chemical industry reduces the impact on the environment during synthesis 5-Bromo-2-iodotoluene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; LEO PHARMA A/S; WO2005/9940; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com