Related Products of 624-76-0,Some common heterocyclic compound, 624-76-0, name is 2-Iodoethanol, molecular formula is C2H5IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
taking theobromine 540mg (3mmoL), NaH 720mg (30mmol) dissolved in 80mL DMF, adding 2mmol of 2-iodoethanol under the drop, after 4 hours of reaction, quenching the reaction with water, spin dry, oil Ether: CH3CH2OCOCH3 = 3:1 (v/v) as a mobile phase over silica gel to give compound 1-ethylhydroxy-3-7-dimethylxanthine, yield 94%.
The synthetic route of 624-76-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sichuan University Huaxi Hospital; Huang Wen; (18 pag.)CN109912598; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com